THE ROLE OF PROBIOTICS AND PREBIOTICS IN GASTROINTESTINAL DISEASES
Keywords:
Probiotics, Prebiotics, Gut Microbiota, Gastrointestinal Diseases, Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), Antibiotic-Associated Diarrhea, Clinical Efficacy, Safety Profiles, Patient PerspectivesAbstract
Probiotics and prebiotics have gained significant attention in recent years for their potential roles in managing gastrointestinal (GI) diseases. This article explores the mechanisms by which probiotics and prebiotics influence gut health, their therapeutic applications in conditions such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and antibiotic-associated diarrhea, and the latest clinical evidence supporting their use. Through a review of recent studies, statistical analysis, and clinical case examples, this article highlights the benefits, limitations, and future directions of probiotic and prebiotic therapies in gastroenterology. Specific quantitative data, safety profiles, and visual aids are included to enhance understanding and provide actionable insights.
References
1. Hill, C. et al. (2017). "Expert Consensus Document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on the Scope and Appropriate Use of the Term Probiotic." Nature Reviews Gastroenterology & Hepatology, 14(8), 491-502.
2. Gibson, G. R. et al. (2017). "Expert Consensus Document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) Consensus Statement on the Definition and Scope of Prebiotics." Nature Reviews Gastroenterology & Hepatology, 14(8), 491-502.
3. Ford, A. C. et al. (2018). "Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis." American Journal of Gastroenterology, 113(11), 1587-1596.
4. Moayyedi, P. et al. (2015). "The Efficacy of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review." Gut, 64(3), 435-442.
5. Suez, J. et al. (2019). "Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT." Cell, 178(6), 1406-1423.
6. Zhang, Y. et al. (2022). "Next-Generation Probiotics: Challenges and Opportunities." Frontiers in Microbiology, 13, 789-801.