METABOLIC STUDIES ON VITAMIN PP (NIACIN) DERIVED FROM MUSHROOMS AND ITS IMPACT ON THE CARDIOVASCULAR SYSTEM
Keywords:
Pleurotus ostreatus, Agaricus bisporus, Vitamin PP, niacin, cardiovascular health, lipid metabolism, mushroomsAbstract
Mushrooms such as Pleurotus ostreatus (oyster mushroom) and Agaricus bisporus (button mushroom) are rich sources of bioactive compounds, including Vitamin PP (niacin), known for its role in cardiovascular health. This study investigates the metabolic effects of niacin derived from these mushrooms on lipid profiles and cardiovascular biomarkers in a controlled animal model. Using Wistar rats, we administered mushroom-derived niacin extracts and assessed serum lipid levels, endothelial function, and oxidative stress markers. Results indicate that niacin from A. bisporus significantly reduced low-density lipoprotein (LDL) cholesterol by 18.4% (p<0.05) and increased high-density lipoprotein (HDL) cholesterol by 12.7% (p<0.05) compared to controls. P. ostreatus extracts showed a 15.2% reduction in triglycerides (p<0.05). Both extracts improved endothelial nitric oxide synthase (eNOS) activity and reduced malondialdehyde (MDA) levels, suggesting enhanced vascular function and reduced oxidative stress. These findings highlight the potential of mushroom-derived niacin as a functional food component for cardiovascular disease prevention.
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