THE ROLE OF SCAVENGER RECEPTORS IN ATHEROSCLEROSIS: BIOCHEMICAL MECHANISMS AND IMPLICATIONS
Keywords:
Atherosclerosis, lipids, scavenger receptors, cardiovascular diseases, low-density lipoprotein (LDL), Nuclear Factor-kappa B (NF-κB)Abstract
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, immune cells, and fibrous elements in the arterial walls. This condition significantly contributes to cardiovascular diseases, including heart attacks and strokes. Among the various cellular components involved in atherosclerosis, scavenger receptors play a pivotal role in the disease's biochemical mechanisms. This article explores the functions of scavenger receptors in atherosclerosis, their contributions to lipid metabolism, inflammation, and potential therapeutic implications.
References
Freedman, J. E., & Egan, B. M. (2016). "The Role of Scavenger Receptors in Atherosclerosis." Cardiovascular Research, 112(2), 171-183. doi:10.1093/cvr/cvw097
Tabas, I., & Glass, C. K. (2013). "Role of Macrophage Cholesterol Efflux in Atherosclerosis." Nature Reviews Immunology, 13(10), 722-732. doi:10.1038/nri3524
Steinberg, D. (2009). "The Cholesterol Hypothesis: Is it Still Relevant?" Journal of the American College of Cardiology, 53(22), 2155-2161. doi:10.1016/j.jacc.2008.12.023
Leitinger, N. (2013). "Scavenger Receptors: Their Role in Inflammation and Atherosclerosis." Current Opinion in Lipidology, 24(5), 524-530. doi:10.1097/MOL.0b013e3283650db5
Huang, J., & Faria, D. (2018). "The Role of CD36 in Lipid Metabolism and Atherosclerosis." Nature Reviews Cardiology, 15(7), 413-421. doi:10.1038/s41569-018-0003-3
Matzinger, P. (2002). "The Danger Model: A Renewed Sense of Self." Science, 296(5576), 301-305. doi:10.1126/science.296.5576.301
Doherty, M. K., & Huang, Y. (2018). "Biomarkers in Atherosclerosis: The Role of Scavenger Receptors." Atherosclerosis, 276, 155-162. doi:10.1016/j.atherosclerosis.2018.07.007
Moore, K.
J., & Tabas, I. (2011). "Macrophages in the Pathogenesis of Atherosclerosis." Cell, 145(3), 341-355. doi:10.1016/j.cell.2011.04.005
Tsimikas, S., & Brilakis, E. S. (2016). "Oxidized Phospholipids: A Link Between Inflammation and Atherosclerosis." Current Atherosclerosis Reports, 18(11), 57. doi:10.1007/s11883-016-0637-7
Zhang, Y., & Yang, K. (2019). "Scavenger Receptors in the Pathogenesis of Atherosclerosis." Cardiovascular Research, 113(11), 1343-1354. doi:10.1093/cvr/cvz012
