YANGI TEXNOLOGIYALAR PRIZMASIDA LEYKOTSIT–TOMIR O‘ZARO TA’SIRI, TOMIR ANATOMIYASINI QAYTA TALQIN QILISH
Keywords:
leykotsit endotelyal adgeziyasi, vaskulyar geografiya, single-cell omika, spatial transcriptomika, intravital mikroskopiya, organ-on-chip, endotelyal geterojenlik, immun-vaskulyar interfeys, yallig‘lanish, tomir barqarorligi.Abstract
Tomir tizimi nafaqat qon oqimi, balki immun tizimning asosiy faol ishtirokchisi sifatida ham xizmat qiladi. Leykotsitlarning tomir devoridagi endoteliylar bilan o‘zaro ta’siri immun javob, yallig‘lanish va patologik jarayonlarni tartibga solishda markaziy o‘rin tutadi. An‘anaviy anatomik talqinlar tomirlarni statik, passiv strukturalar sifatida ko‘rib chiqgan bo‘lsa-da, yangi texnologiyalar ularning dinamik, heterojen va murakkab fiziologik vazifalarini ochib berdi. Ushbu sharhli maqolada single-cell RNK ketma-ketlashtirish (scRNA-seq), spatial transcriptomika, intravital mikroskopiya va organ-on-chip kabi innovatsion usullar yordamida so‘nggi o‘n yil ichida (2015-2025) erishilgan fundamental tushunchalarni qayta ko‘rib chiqamiz. Bu metodologiyalar leykotsit endotelyal adgeziyasini, migratsiyasini va signallashuvini nazorat qiluvchi molekulyar mexanizmlarni noan'anaviy aniqlik bilan ochib berdi, shuningdek, turli organlardagi tomirlarning tizimli funksional va fenotipik farqlarini (vaskulyar geografiya) aniqladi. Ushbu fanlararo yondashuv tomirlarni yallig‘lanish, o‘smalar, avtoimmun va yurak-qon tomir kasalliklarida o‘zgarishlar kontekstida qayta talqin qilish imkonini beradi, bu esa yangi terapevtik strategiyalar uchun asos bo‘lishi mumkin.
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