HYPOTENSIVE EFFECT OF PLANT ALKALOIDS ON SMOOTH MUSCLES.
Keywords:
alkaloids, smooth muscles, hypotensive, aorta, nervous system, plant alkaloids.Abstract
There are many plants on the globe that are widely used in medicine and pharmacology. Among the known plants with medicinal properties, a special place is occupied by alkaloid plants, plants with a high nitrogen content. Natural alkaloids are organic compounds containing nitrogen and possessing a variety of pharmacological activity, including a vasodilatory effect. Many of them can affect calcium channels, as well as other molecular targets in the cells of the vascular wall, which affects the tone of the vessels.
References
1. Cheng H.P., Wei S., Wei L.P. et al. Calcium signaling in physiology and pathophysiology // Acta Pharmacologica Sinica. – 2006. – V.27(7). – P.767–772.
2. Bakievа Мuazzam, Anvar Zaynabiddinov, Pulat Usmanov,
Biophysics and Biochemistry at the National University of Uzbekistan
Vazorelaxant effect of 6-O-benzoygeteratisine, aditerpene alkaloid on functional activity of rat aorta smooth muscule cells.2019.
3. Niemeyer B.A., Lery M., Zavar C. et al. Ion channels in health and disease // EMBO Reports. – 2001. – V.2(7). –P.568–573.
4. Jenitsch T., Hubner C.A.., Fuhrmann J. Ion channels: Function unraveled by dysfunction // Nature Cell Biology. –2004. – V.6. – P.1039–1047.
5. Nilius B., Viana F., Droogmans G. Ion channels in vascular endothelium // Annual Review of Physiology. – 1997. –V. 59. – P.145–170
6. Bakieva Muazzam Sharifzhanovna, Abdujalilova Begoyim Ulugbek kizi Namangan State University. Department of Human Anatomy and Physiology. ANTISPASMATIC EFFECT OF PLANT ALKALOIDS ON SMOOTH MUSCLES.2024.
7. Solovg’ev A.I. Ionnqe kanalq kak farmakologicheskie misheni. Vremya smenq ‘aradigm klassicheskoy farmakotera’ii // Farmakologіya ta lіkarsg’ka toksikologіya.–2013. – №6(36). – S.101–106.
8. Li, N., Sanyour, H., Remund, T., Kelly, P., and Hong, Z. (2018). Vascular extracellular matrix and fibroblasts-coculture directed differentiation of human mesenchymal stem cells toward smooth muscle-like cells for vascular tissue engineering. Mater. Sci. Eng. C 93, 61-69. doi: 10.1016/j.msec.2018.07.061.
9. Hartman, C. D., Isenberg, B. C., Chua, S. G., and Wong, J. Y. (2016). Vascular smooth muscle cell durotaxis depends on extracellular matrix composition. Proc. Natl. Acad. Sci. USA 113, 11190-11195. doi: 10.1073/pnas.1611324113.
10. Leloup, A. J. A., Van Hove, C. E., De Moudt, S., De Meyer, G. R. Y., De Keulenaer, G. W., and Fransen, P. (2019). Vascular smooth muscle cell contraction and relaxation in the isolated aorta: a critical regulator of large artery compliance. Physiol. Rep. 7:e13934. doi: 10.14814/phy2.13934.
11. O'Rourke B., Kass D.A., Tomaselli G.F., Kaab S., Tunin R., Marban E. Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure // Circ. Res. - 1999. - V. 84. - P. 562-570.
12. Huang, H., Sun, Z., Hill, M. A., and Meininger, G. A. (2018). A calcium medicated mechanism coordinating vascular smooth muscle cell adhesion during KCl activation. Front. Physiol. 9:a1810. doi: 10.3389/fphys.2018.01810.
13. Influence of atisine alkaloid on contractile activity of smooth muscle cell aorta. Muazzam Bakieva, Anvar Zaynabiddinov , Pulat Usmanov, Institute of Biophysics and Biochemistry atthe National Universityof Uzbekistan.2019.
14. Pogwizd S.M., Qi M., Yuan W., Samarel A.M., Bers D.M. Upregulation of Na+/Ca2+-exchanger expression and function in an arrhythmogenic rabbit model of heart failure // Circ. Res. - 1999. - V. 85. - P. 1009-1019.
15. Cribbs L.L.Vascular Smooth Muscle Calcium Channels.Could T be a target // Circ. Res. - 2001. - V. 89. - P. 560-567.
16. Sanders K.M. Signal transduction in smooth muscle: mechanisms of calcium handling in smooth muscles // J. Appl. Physiol. - 2001. - V. 91. - P. 14381449.
17. Jaggar J.H., Porter V., Nelson M.T. Calcium sparks in smooth muscle // Am. J. Physiol.- 2000. V. 278. - P. 235-256.
