THE EFFECT OF CHITOSAN AND WHEY POWDER COMBINATION ON CALCIUM-PHOSPHORUS METABOLISM AND BONE MINERALIZATION
Keywords:
chitosan, whey powder, calcium-phosphorus metabolism, osteogenesis, bone mineralization, composite scaffold, mesenchymal stem cells.Abstract
This scientific article analyzes the effect of the combination of chitosan and whey powder on calcium-phosphorus metabolism and bone tissue mineralization processes based on modern scientific literature. Chitosan, as a natural biopolymer, possesses high biocompatibility, biodegradability, chelating properties, and the capacity to create an osteoconductive environment, making it a promising scaffold material in bone tissue engineering [4–6]. Whey powder serves as a source of biologically active proteins and mineral components, potentially supporting bone cell metabolism and the formation of the protein-mineral matrix [3,7,8]. The article highlights in vitro approaches concerning mesenchymal stem cell adhesion, osteoblastic differentiation, and mineral deposit formation on chitosan-based modified surfaces, as well as prospects for developing composite scaffolds combined with whey proteins [8–10]. Findings indicate that the combination of chitosan and whey powder has scientific grounds to promote bone mineralization and may serve as an additional prophylactic and biomaterial solution in conditions such as osteoporosis.
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