OZIQLANISH VA ENERGETIK GOMEOSTAZNING LEPTIN, GRELIN VA OREKSIN GORMONLARI ORQALI INTEGRATSION NAZORATI
Keywords:
leptin, grelin, oreksin, energetik gomeostaz, ishtaha, semizlik, gipotalamus, neyropeptidlar, metabolik sindrom.Abstract
Ushbu maqolada inson organizmidagi oziqlanish va energetik gomeostazni tartibga soluvchi asosiy gormonlar - leptin, grelin va oreksinning integratsion nazorati tizimi chuqur tahlii qilinadi. [1] So'nggi o'n yil ichida olib borilgan tadqiqotlar shuni ko'rsatdiki, bu gormonlar nafaqat ishtaha va energiya sarfini boshqaradi, balki metabolik jarayonlar, immunitet tizimi, reproduktiv funktsiyalar va hatto kognitiv qobiliyatlar bilan ham chambarchas bog'liq. [2] Maqolada bu gormonlarning molekulyar mexanizmlari, o'zaro ta'sirlari va ularning buzilishi natijasida yuzaga keladigan metabolik kasalliklar (semizlik, qandli diabet va boshqalar)ning patofiziologik asoslari yoritilgan. [3] Tadqiqotda zamonaviy ilmiy adabiyotlar va 2015-2025-yillarda o'tkazilgan klinik tadqiqotlar natijalari tahlii qilingan bo'lib, ular ushbu gormonlarning terapevtik potensialini ochib beradi. [4]
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