SURUNKALI DEPRESSIYANI DAVOLASHDA YANGI AVLOD ANTIDEPRESSANTLARI VA ULARNING SAMARADORLIGI.
Keywords:
Surunkali depressiya, antidepressantlar, yangi avlod dori vositalari, SSRI, SNRI, neyrotransmitterlar, serotonin, dopamin, norepinefrin, psixofarmakologiya, ruhiy salomatlikAbstract
Surunkali depressiya (persistant depressiv buzilish) zamonaviy psixiatriyada dolzarb muammolardan biri bo‘lib, uning uzoq davom etishi va davolashga turlicha javob berishi bilan ajralib turadi. So‘nggi yillarda yangi avlod antidepressantlarining yaratilishi ushbu kasallikni davolashda muhim yutuqlarga olib keldi. Bu dori vositalari an’anaviy antidepressantlarga nisbatan yuqori samaradorlik, tezroq ta’sir boshlanishi va kamroq nojo‘ya ta’sirlari bilan tavsiflanadi. Yangi avlod antidepressantlariga selektiv serotonin qayta qabul qilinish ingibitorlari (SSRIs), serotonin-norepinefrin qayta qabul qilinish ingibitorlari (SNRIs), hamda multimodal ta’sirga ega preparatlar kiradi. Ular miya neyrotransmitter tizimlariga — ayniqsa serotonin, dopamin va norepinefrin almashinuviga ta’sir ko‘rsatib, ruhiy holatni barqarorlashtirish, kayfiyatni yaxshilash va motivatsiyani oshirishga yordam beradi. Tadqiqotlar shuni ko‘rsatadiki, yangi avlod antidepressantlari surunkali depressiya simptomlarini kamaytirishda samarali bo‘lib, bemorlarning hayot sifatini sezilarli darajada yaxshilaydi. Shu bilan birga, ularning samaradorligi individual xususiyatlarga bog‘liq bo‘lib, davolash jarayonida shaxsga yo‘naltirilgan yondashuv muhim ahamiyat kasb etadi.
References
1. Akmaljon o'g'li, R. A. (2025). NEUROBIOLOGICAL MECHANISMS AND MODERN TREATMENT APPROACHES IN DEPRESSIVE DISORDERS. AMERICAN JOURNAL OF APPLIED MEDICAL SCIENCE, 3(11), 357-362.
2. AZAMAT, G., KOMIL, A., HALIMA, U., & ALISHER, E. (2020). New device and technology for primary processing of silkworm cocoons obtained during different feeding seasons. INTERNATIONAL JOURNAL, 8(5), 5118-5122.
3. Uralov, B., Eshev, S., Norkobilov, A., Vokhidov, O., Rakhimov, A., Arzieva, D., &Salimbayeva, I. (2023). Design parameters of water intake chambers on water supply channels of pumping stations. In E3S Web of Conferences (Vol. 410, p. 05034). EDP Sciences. 4. Eshbobaev, J., Rakhimov, A., Norkobilov, A., Usmanov, K., Turakulov, Z., Kamolov, A., ...&Khamidov, B. (2026). Comparison of intelligent and traditional control systems in wastewater treatment process control. Engineering Proceedings, 124(1), 4029.
5. Rakhimov, A., Bozorov, R., Tuychiev, A., Mutalov, S., Eshbobaev, J., &Jabborov, A. (2026). Development of an ANFIS-Based Intelligent Control System for Free Chlorine Removal from Industrial Wastewater Using Ion-Exchange Resin. Engineering Proceedings, 117(1), 28.
6. Rakhimov, A., Bozorov, R., Mutalov, S., Eshbobaev, J., Yusupov, M., Islomova, F., &Yunusov, B. (2026). An Intelligent Prediction–Optimization Framework for Free Chlorine Removal from Industrial Wastewater Using Activated Carbon Filtration. Engineering Proceedings, 124(1), 50.
7. Rakhimov, A., Eshbobaev, J., &Bozorov, R. (2025). Efficient Dechlorination of Industrial Wastewater via Optimized Activated Carbon Filtration.
8. Rakhimov, A., Murodov, H., Igitov, F., &Eshbobaev, J. (2025). ANFIS-based intelligent control of chlorine removal in the industrial wastewater treatment process.
9. Rakhimov, A., Jurayev, R., Turayev, K., &Togasharov, A. (2024). SYNTHESIS OF HERBICIDES BASED ON P-CHLOROPHENOL: STUDY OF POLYTHERMAL SOLUBILITY OF SYSTEM NAOH–CL-C6H4OH-H2O.
10. US, U. K., Rakhimov, A. A., &Djuraev, J. A. (2023). Burunbo'shlig'iturlipatologiyalardasimultanjarroxlikaralashuvlaridankeyingiklinik–funksionalnatijalar. Eurasian Journal of Otorhinolaryngology-Head and Neck Surgery, 2, 26-30.
11. Saidakramovich, K. U., &Abdukakharovich, D. J. (2022). EFFECTIVENESS USING OF SILICON SPLINTS IN SURGICAL PROCEDURES ON THE MUCOUS MEMBRANE OF THE CAVITY OF THE NOSE.
12. Saidakramovich, K. U. (2022). MORPHOLOGICAL CHARACTERISTICS OF THE MUCOSA OF CAVITY OF THE NOSE AFTER VARIOUS SURGICAL PROCEDURES.
13. Abdullaev, S., Rakhimov, A., Umarov, A. A., Nouwens, V., Bos, L., Pantucci, R., ...&Andžāns, M. No. 2 Political and security relations-Mapping Central Asia’s relations with other Asian states.
14. RAKHIMOV, A., UMAROV, A., & KHASANOV, U. The New Dynamics of Uzbekistan's Foreign Policy Since the beginning of the 1990s, the regional and international position of Uzbekistan has becomea major factor in determining the geopolitics of Central Asia. In the early years of independence, the leadership of Uzbekistan seriously highlighted the existence of.
15. Умарова, М., & Кодиржонов, Н. (2022). ТРОМБОЛИТИЧЕСКАЯ ТЕРАПИЯ В ЛЕЧЕНИИ ИШЕМИЧЕСКОГО ИНСУЛЬТА. Theoretical aspects in the formation of pedagogical sciences, 1(5), 218-220.
16. Умарова, М. (2021). ИНСОМНИА ВА МЕТАБОЛИК СИНДРОМНИНГ ЎЗАРО КОМОРБИДЛИГИ МУАММОНИНГ ДОЛЗАРБЛИГИ. Интернаука, (20-7), 29-30.
17. Умарова, М. (2021). МИГРЕН КАСАЛЛИГИ ВА УНИНГ ШОШИЛИНЧ ТЕРАПИЯСИНИ ТАКОМИЛЛАШТИРИШ. ИНТЕРНАУКА Учредители: Общество с ограниченной ответственностью" Интернаука, 93-94.
18. Умарова, М. (2021). ИНСУЛТДАН КЕЙИНГИ ТАЛВАСА СИНДРОМИ. Интернаука, (18-5), 46-48.
19. Rakhmatova, M., Shakhanova, S., Nazarova, J., Azizova, F., Astanakulov, D., Akramov, G., &Mirametova, N. (2024). Brain tumor information retrieval system for brain tumor diagnosis. Health Leadership and Quality of Life, (3), 10.
20. RAKHMATOVA, M., SHAKHANOVA, S., NAZAROVA, J., AZIZOVA, F., ASTANAKULOV, D., AKRAMOV, G., & MIRAMETOVA, N. (2024). BRAIN TUMOR INFORMATION RETRIEVAL SYSTEM FOR BRAIN TUMOR DIAGNOSIS. HEALTH, 3.
21. Soyibjono'g, A. G. A. THE EFFECTIVENESS OF COMBINING PSYCHOTHERAPY AND PHARMACOTHERAPY IN THE TREATMENT OF MENTAL DISORDERS.
22. Soyibjono'g, A. G. A. TYPOLOGY OF ANXIETY-PHOBIC DISORDERS.
