REM UYQUNING NEYROFIZIOLOGIK MEXANIZMLARI: KLASSIK MODELLAR, NEYROMEDIATORLAR DINAMIKASI VA ONTOGENEZ DAVOMIDA FUNKSIONAL AHAMIYATI
Keywords:
REM uyqu, uyqu fiziologiyasi, REM-on / REM-off mexanizmlari, neyromediatorlar, dofamin, tushlar, miya rivojlanishi, neyrotasvirlash.Abstract
Tezkor ko‘z harakatlari bilan kechuvchi uyqu (REM uyqu) yuqori kortikal faollik, yorqin tushlar va mushak atoniyasi bilan tavsiflanadigan o‘ziga xos neyrofiziologik holat hisoblanadi. REM uyqu davridagi elektroensefalografik ko‘rsatkichlar uyg‘oqlik holatida kuzatiladigan naqshlarga o‘xshash bo‘lsa-da, po‘stloq osti tuzilmalarining faollashuv mexanizmlari va ularning funksional oqibatlari hali to‘liq o‘rganilmagan. Ushbu sharh maqola REM uyquning klassik neyrofiziologik modellarini neyrotasvirlash va neyrokimyoviy tadqiqotlarning so‘nggi natijalari bilan integratsiya qilgan holda REM uyqu regulyatsiyasiga yangilangan va keng qamrovli qarashni taqdim etadi. Maqolada REM-on va REM-off neyron tizimlariga, shuningdek asetilxolin, glutamat va dofaminning REM uyquni hamda tushlar bilan bog‘liq emotsional tajribalarni modulyatsiya qilishdagi roliga alohida e’tibor qaratilgan. Bundan tashqari, REM uyquning ontogenez davomida tutgan o‘rni tahlil qilinib, uning erta miya rivojlanishidagi hal qiluvchi ahamiyati, shuningdek kattalarda xotira mustahkamlanishi, emotsional regulyatsiya va moslashuvchan xulq-atvor jarayonlaridagi ishtiroki yoritib beriladi. REM uyqu regulyatsiyasining buzilishi bilan bog‘liq nevrologik va psixiatrik kasalliklar nuqtayi nazaridan uning klinik ahamiyati ham muhokama qilinadi.
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