OQSIL BIOSINTEZI INGIBITORLARI: DORI VOSITALARI VA BAKTERIAL TOKSINLAR
Keywords:
oqsil biosintezi, ribosoma, antibiotiklar, bakterial toksinlar, PrAMP, 50S subbirlik, 30S subbirlik, antimikrob qarshilikAbstract
Ushbu maqolada oqsil biosintezi ingibitorlarining ta’sir mexanizmlari, dori vositalari sifatidagi roli va bakterial toksinlar bilan aloqadorligi yoritilgan. Ribosoma oqsil sintezining markaziy organoidi bo‘lib, ko‘plab antibiotiklar va toksinlar uchun nishon sanaladi. Zamonaviy ilmiy adabiyotlar tahlili 50S va 30S ribosomal subbirliklarga ta’sir etuvchi makrolidlar, tetratsiklinlar, aminoglikozidlar, shuningdek, prolinga boy antimikrob peptidlar (PrAMP) kabi noyob tabiiy birikmalar mavjudligini ko‘rsatadi. Maqolada O‘zbekiston olimlari tomonidan olib borilgan tadqiqotlar, xalqaro ilmiy nashrlar va ishonchli veb-manbalar asosida ushbu ingibitorlarning molekulyar mexanizmlari va klinik ahamiyati muhokama qilinadi.
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