ALOE VERA VA UNING ASOSIY FAOL MODDALARINING TIBBIYOTDAGI AHAMIYATI (ADABIYOTLAR SHARHI)
Keywords:
Aloe vera; ekstraktlar; izolyatsiya qilingan birikmalar; farmakologiya.Abstract
Aloe vera an'anaviy ravishda terining shikastlanishi (kuyishlar, kesishlar, hasharotlar chaqishi va ekzema) va ovqat hazm qilish muammolarini davolash uchun ishlatilgan, chunki uning yallig'lanishga qarshi, mikroblarga qarshi va yaralarni davolovchi xususiyatlari haqidagi ma’lumotlar qadimdan ma’lum. Ushbu dorivor o‘simlik bo‘yicha tadqiqotlar an'anaviy foydalanishni tasdiqlash va ta'sir mexanizmini chuqurlashtirish, ushbu faoliyat uchun mas'ul bo‘lgan birikmalarni aniqlashga qaratilgan. Eng ko‘p o‘rganilgan faol birikmalar aloe-emodin, aloin, aloesin, emodin va acemannan. Xuddi shunday, aloe vera va uning faol birikmalari uchun yangi adabiyotlar o‘rganildi. Ushbu sharh so‘nggi olti yil davomida (2014-2019) ingliz tilida yozilgan joriy farmakologik tadqiqotlar (in vitro, in vivo va klinik sinovlar) haqida umumiy ma'lumot beradi. Xususan, farmakologik ma'lumotlarning yangi tadqiqotlari shuni ko‘rsatdiki, ko‘pchilik tadqiqotlar saratonga qarshi ta'sirga, teri va ovqat hazm qilish tizimining himoya faolligiga va mikroblarga qarshi xususiyatlarga ishora qiladi. Klinik sinovlar faqat aloe vera bilan o‘tkazildi, lekin izolyatsiya qilingan birikmalar bilan emas; shuning uchun insonning turli sharoitlari va patologiyalarida tegishli metabolitlarning klinik ta'sirini o‘rganish qiziqarli bo‘ladi. Asosiy tadqiqotlardagi ushbu tadqiqotlarning istiqbolli natijalari aloe vera va uning asosiy birikmalarini, xususan, suyaklarni himoya qilish, saraton va diabet kasalligida klinik qo‘llanilishini sinab ko‘rish uchun ko‘proq klinik sinovlarni kuchaytiradi.
References
1. Surjushe, A.; Vasani, R.; Saple, D.G. Aloe vera: A short review. Indian J. Dermatol. 2008, 53, 163–166. [Google Scholar] [CrossRef]
2. Malik, I.; Zarnigar, H.N. Aloe vera-A Review of its Clinical Effectiveness. Int. Res. J. Phar. 2003, 4, 75–79. [Google Scholar] [CrossRef]
3. Maan, A.A.; Nazir, A.; Khan, M.K.I.; Ahmad, T.; Zia, R.; Murid, M.; Abrar, M. The therapeutic properties and applications of Aloe vera: A review. J. Herb. Med. 2018, 12, 1–10. [Google Scholar] [CrossRef]
4. Sholehvar, F.; Mehrabani, D.; Yaghmaei, P.; Vahdati, A. The effect of Aloe vera gel on viability of dental pulp stem cells. Dent. Traumatol. 2016, 32, 390–396. [Google Scholar] [CrossRef]
5. Lin, H.; Honglang, L.; Weifeng, L.; Junmin, C.; Jiantao, Y.; Junjing, G. The mechanism of alopolysaccharide protecting ulceralive colitis. Bio. Pharm. 2017, 88, 145–150. [Google Scholar] [CrossRef]
6. Songsiripradubboon, S.; Kladkaew, S.; Trairatvorakul, C.; Sangvanich, P.; Soontornvipart, K.; Banlunara, W.; Thunyakitpisal, P. Stimulation of dentin regeneration by using acemannan in teeth with lipopolysaccharide-induced pulp inflammation. J. Endod. 2017, 43, 1097–1103. [Google Scholar] [CrossRef]
7. Nejaim, Y.; Silva, A.I.; Vasconcelos, T.V.; Silva, E.J.; de Almeida, S.M. Evaluation of radioprotective effect of Aloe vera and zinc/copper compounds against salivary dysfunction in irradiated rats. J. Oral Sci. 2014, 56, 191–194. [Google Scholar] [CrossRef] [Green Version]
8. Kumar, G.R.; Devanand, G.; John, B.D.; Ankit, Y.; Khursheed, O.; Sumit, M. Preliminary antiplaque efficacy of Aloe vera mouthwash on 4 day plaque re-growth model: Randomized control trial. Ethiop. J. Health Sci. 2014, 24, 139–144. [Google Scholar] [CrossRef] [Green Version]
9. Pradeep, A.R.; Garg, V.; Raju, A.; Singh, P. Adjunctive local delivery of Aloe vera gel in patients with type 2 diabetes and chronic periodontitis: A randomized, controlled clinical trial. J. Periodontol. 2016, 87, 268–274. [Google Scholar] [CrossRef]
10. Vangipuram, S.; Jha, A.; Bhashyam, M. Comparative efficacy of Aloe vera mouthwash and chlorhexidine on periodontal health: A randomized controlled trial. J. Clin. Exp. Dent. 2016, 8, e442. [Google Scholar] [CrossRef]
11. Yeturu, S.K.; Acharya, S.; Urala, A.S.; Pentapati, K.C. Effect of Aloe vera, chlorine dioxide, and chlorhexidine mouth rinses on plaque and gingivitis: A randomized controlled trial. J. Oral Bio. Craniofac. Res. 2016, 6, 55–59. [Google Scholar] [CrossRef] [PubMed] [Green Version]
12. Moghaddam, A.A.; Radafshar, G.; Jahandideh, Y.; Kakaei, N. Clinical evaluation of effects of local application of Aloe vera gel as an adjunct to scaling and root planning in patients with chronic periodontitis. J. Dent. 2017, 18, 165–172. [Google Scholar]
13. Ipshita, S.; Kurian, I.G.; Dileep, P.; Kumar, S.; Singh, P.; Pradeep, A.R. One percent alendronate and Aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: A randomized, controlled clinical trial. J. Investig. Clin. Dent. 2018, 9, e12334. [Google Scholar] [CrossRef]
14. Kurian, I.G.; Dileep, P.; Ipshita, S.; Pradeep, A.R. Comparative evaluation of subgingivally-delivered 1% metformin and Aloe vera gel in the treatment of intrabony defects in chronic periodontitis patients: A randomized, controlled clinical trial. J. Investig. Clin. Dent. 2018, 9, e12324. [Google Scholar] [CrossRef]
15. Fallahi, H.R.; Hamadzade, H.; Nezhad, A.M.; Zandian, D.; Taghizadeh, M. Effect of Aloe vera mouthwash on postoperative complications after impacted third molar surgery: A randomized, double-blind clinical trial. J. Oral Maxillofac. Surg. Med. Path. 2016, 28, 392–396. [Google Scholar] [CrossRef]
16. Khakimov Z. Z. et al. Effect of Derivatives of Glycyrrhetic Acid on the Intensity of Free Radical Processes During Immobilization Stress //Texas Journal of Medical Science. – 2022. – Т. 8. – С. 1-5.
17. Djanaev G. Y., Mamadjanova M. A. Effect on the Organism When Chronic Administration of a New Phytopreparation //Scholastic: Journal of Natural and Medical Education. – 2023. – Т. 2. – №. 4. – С. 188-195.
18. Djanayev G. Y. Dorivor o‘simliklar quruq ekstraktining rezerpinli me'da yarasiga ta'siri : дис. – Tibbiyotdagi zamonaviy ilmiy tadqiqotlar, 2022.
19. YU D. G., ALLAYEVA M. J. Оценка эффективности нового препарата сэлр в профилактики и лечении гастропатий. – 2022.
20. Джанаев Г. Ю. Уткир токсик гепатитда глицерамнинг сафро ва унинг таркибидаги моддаларнинг экскрециясига таъсирини ўрганиш. – 2020.
21. Аллаева М. Ж., Джанаев Г. Ю., Ачилов Д. Д. Achillea millefolium l. ўсимлиги қуруқ экстрактининг қон ивиш жараёнига таъсирини ўрганиш изучение влияния сухого экстракта achillea millefolium l. на свертывающее системы крови Тошкент тиббиёт академияси //ЎЗБЕКИСТОН ФАРМАЦЕВТИК ХАБАРНОМАСИ. – Т. 61.
22. Djanaev G. Y. et al. Comparative Study of the Influence of Lesbochole, Misoprostol and Mucagen on the Gastric Mucous Barrier in Indometacin Gastropathy //VOLUME03 ISSUE06 Pages. – Т. 11. – №. 23. – С. 130-133.
23. Djanaev, G. Y., Sh, M., Mamadzhanova, M. A., & Kholmatov, J. A. (2023). Pharmacotherapeutic effectiveness of herbal medicine" yazvanol" in the experimental indomethacine gastropaty model. World Bulletin of Public Health, 21, 144-147.
24. Хакимов З., Джанаев Г., Холматов Ж. Прокинетическая активность нового фитопрепарата «ЛЕСБОХОЛ» //Евразийский журнал медицинских и естественных наук. – 2022. – Т. 2. – №. 13. – С. 205-209.
25. Khakimov, Z. Z., and G. Yu Djanaev. "Askarov OO Study Of the Effect of a Mixture of Extracts of Medicinal Plants on the State of the Gastric Mucosa in Gastropathy Induced by Indomethacin." Eurasian Medical Research Periodical 19 (2023): 90-95.
26. Djanaev G. Y., Askarov O. O., Sultanov S. A. Phytotherapy of Gastric Ulcer (Literature Review) //Texas Journal of Medical Science. – 2022. – Т. 15. – С. 51-59.
27. Аллаева, М. Ж., Ачилов, Д. Д., Кдырниязова, С. A., & Аскаров, O. O. Фармакологические свойства сухого экстракта convolvulus arvensis l. convolvulus arvensis l. қуруқ экстрактининг фармакологик хусусиятлари Ташкентская медицинская академия. Ўзбекистон фармацевтик хабарномаси, 70.
28. Kalra, M.; Garg, N.; Rallan, M.; Pathivada, L.; Yeluri, R. Comparative evaluation of fresh Aloe barbadensis plant extract and mineral trioxide aggregate as pulpotomy agents in primary molars: A 12-month follow-up study. Contemp. Clin. Dent. 2017, 8, 106–111. [Google Scholar]
29. Nimma, V.L.; Talla, H.V.; Bairi, J.K.; Gopaldas, M.; Bathula, H.; Vangdoth, S. Holistic healing through herbs: Effectiveness of Aloe vera on post extraction socket healing. J. Clin. Diagn. Res. 2017, 11, 83–86. [Google Scholar] [CrossRef]
30. Prabhakar, A.R.; Karuna, Y.M.; Yavagal, C.; Deepak, B.M. Cavity disinfection in minimally invasive dentistry-comparative evaluation of Aloe vera and propolis: A randomized clinical trial. Contemp. Clin. Dent. 2015, 6, S24–S31. [Google Scholar] [CrossRef]
31. Sahebjamee, M.; Mansourian, A.; Mohammad, M.H.; Zadeh, M.T.; Bekhradi, R.; Kazemian, A.; Doroudgar, K. Comparative efficacy of Aloe vera and benzydamine mouthwashes on radiation-induced oral mucositis: A triple-blind, randomised, controlled clinical trial. Oral Health Prev. Dent. 2015, 13, 309–315. [Google Scholar]
32. Mansouri, P.; Haghighi, M.; Beheshtipour, N.; Ramzi, M. The effect of Aloe vera solution on chemotherapy-induced stomatitis in clients with lymphoma and leukemia: A randomized controlled clinical trial. Int. J. Community Nurs. Midwifery 2016, 4, 119–126. [Google Scholar]
33. Anuradha, A.; Patil, B.; Asha, V.R. Evaluation of efficacy of Aloe vera in the treatment of oral submucous fibrosis–a clinical study. J. Oral Path. Med. 2017, 46, 50–55. [Google Scholar] [CrossRef] [PubMed]
34. Sánchez M, González-Burgos E, Iglesias I, Gómez-Serranillos MP. Pharmacological Update Properties of Aloe Vera and its Major Active Constituents. Molecules. 2020 Mar 13;25(6):1324. doi: 10.3390/molecules25061324. PMID: 32183224; PMCID: PMC7144722.
