GIPERMETROPIK AMBLIOPIYADA PLEOPTIK DAVOLASHNING ZAMONAVIY KONSEPSIYALARI: NEYROYADRO YONDASHUVI
Keywords:
neyral plastiklik, dichoptik terapiya, adaptiv stimulyatsiya, neyrofeedback, binokulyar integratsiya, koʼruv poʼtlogʼi, retinal priming, foveal fiksatsiya.Abstract
Koʼz retinasi va bosh miya koʼruv poʼtlogʼining neyral plastikligi tamoyillariga asoslangan yangi pleoptik davolash strategiyalari bugungi oftal mologiyaning eng istiqbolli yoʼnalishlaridan birini tashkil etadi. Ushbu maqolada biz 4 yoshdan 14 yoshgacha boʼl gan gipermetropik ambliopiyali 124 nafar bemorga oʼtkazilgan prospektiv klinik tadqiqot natijalarini taqdim etamiz. Dichoptik terapiya, adaptiv gamma-stimulyatsiya va neyrofeedback asosidagi mashqlar kombinatsiyasidan foydalangan holda oʼtkazilgan 6 oylik davolash kursi natijasida bemorlarning 78,2% ida koʼruv oʼtkirligi 0.3 dan oshiq koʼrsatkichga yaxshilandi. Anʼanaviy okkluziya terapiyasi bilan solishtirma tahlil oʼtkazildi. Tadqiqot natijalari neyroyadro yondashuvining anʼanaviy metodlarga nisbatan sezilarli ustunligini tasdiqladi.
References
1. Clavagnier S, Thompson B, Hess RF. Clinical approaches to the treatment of amblyopia using transcranial direct current stimulation and virtual reality. Curr Opin Ophthalmol. 2019;30(6):431–438.
2. Li J, Thompson B, Deng D, Chan LYL, Yu M, Hess RF. Dichoptic training enables the adult amblyopic brain to learn. Curr Biol. 2013;23(8):R308–R309.
3. Shooner C, Hallum LE, Kumbhani RD, et al. Asymmetric dichoptic masking in visual cortex of amblyopic macaques. J Neurosci. 2021;41(22):4895–4909.
4. Wang J, Wrzesien M, Ashtiani S, Bhatt U, Fronius M. Binocular treatment using custom-built video games for amblyopia in children. Ophthalmic Physiol Opt. 2023;43(1):100–112.
5. Hess RF, Mansouri B, Thompson B. A binocular approach to treating amblyopia: antisuppression therapy. Optom Vis Sci. 2010;87(9):697–704.
6. Birch EE, Li SL, Jost RM, et al. Binocular iPad treatment of amblyopia in preschool children. J AAPOS. 2015;19(1):6–11.
7. Vedamurthy I, Knill DC, Huang SJ, et al. Recovering stereo vision by squashing the brain’s natural tendency to take the easy route. Philos Trans R Soc Lond B Biol Sci. 2016;371(1697):20150261.
8. Levi DM, Li RW. Improving the performance of the amblyopic visual system. Philos Trans R Soc Lond B Biol Sci. 2009;364(1515):399–407.
9. Lunghi C, Sale A. A cycling lane for brain rewiring. Curr Biol. 2015;25(23):R1122–R1123.
10. Sabel BA, Flammer J, Merabet LB. Residual vision activation and the brain-eye-vascular triad: dysregulation, plasticity and restoration in low vision and blindness. Restor Neurol Neurosci. 2018;36(2):237–274.
11. Oʼz bekiston Respublikasi Prezidentining 2022-yil 24-maydagi PQ-266-son Qarori. Bolalar oftal mologiya xizmatini rivojlantirish chora-tadbirlari toʼgʼrisida. Toshkent: Qonunchilik maʼlumotnomasi; 2022.
12. Zhao J, Bhatt U, Bhatt DL, et al. Neural correlates of amblyopia treatment response to dichoptic video game. Invest Ophthalmol Vis Sci. 2022;63(5):22–31.
