THE ROLE OF THYROID FUNCTIONAL DISORDERS IN AUTOIMMUNE PROCESSES AND THEIR ASSOCIATION WITH THE DEVELOPMENT OF RHEUMATOID POLYARTHRITIS
Keywords:
rheumatoid arthritis; rheumatoid polyarthritis; autoimmune thyroid disease; Hashimoto's thyroiditis; Graves' disease; hypothyroidism; subclinical hypothyroidism; hyperthyroidism; anti TPO; anti Tg; TRAb; ACPA; RF; Th17/Treg; TNF α; IL 6; IL 17; deiodinase; comorbidity; treatment interaction.Abstract
A systematic analysis of the epidemiological association, immunopathogenetic mechanisms, clinical-diagnostic "overlap points", therapeutic interactions, and prognostic impact between thyroid functional disorders/autoimmune thyroid diseases and rheumatoid arthritis (rheumatoid polyarthritis) based on contemporary primary literature and official clinical guidelines. Meta-analyses, cohort/observational studies, Mendelian randomization investigations published during 2010–2026, as well as official recommendations in rheumatology and thyroidology (ACR/EULAR/ATA/ETA and regional protocols) were selected, and an integrative logical model and diagnostic algorithm for clinical practice were developed.
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